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Clinical Research Trials

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(-) Thoracic Cancer
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Status

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Accepting Participants
Complete

Disease Site

Oncology
Symptom Management & Cancer Control
Breast Cancer
(-) Thoracic Cancer
Hematologic Cancer
Gastrointestinal Cancer
Genitourinary Cancer
Precision Medicine & Rare Tumors
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Cancer Care Delivery Research (CCDR)
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Study Type

Treatment

Oncology

Thoracic Cancer

A Phase III, Randomized, Multicenter, Double-blind, Placebo-controlled Study to Determine the Efficacy of Adjuvant Durvalumab in Combination With Platinum-based Chemotherapy in Completely Resected Stage II-III NSCLC (Mermaid-1)
Closed
Adenoma and Second Primary Prevention Trial (S0820)
Closed
Limited Stage Small Cell Lung Cancer (LS-SCLC): A Phase II/III Randomized Study of Chemoradiation Versus Chemoradiation Plus Atezolizumab (NRG-LU005)
Closed
LUNGMAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer, (Screening Study)
Closed
MRI Brain Surveillance Alone Versus MRI Surveillance and Prophylactic Cranial Irradiation (PCI): A Randomized Phase III Trial in Small-Cell Lung Cancer (MAVERICK) (S1827)
Accepting Participants
Non-small Cell Lung Cancer (NSCLC), Metastatic (NRG LU-002)
Complete
Non-small Cell Lung Cancer ALCHEMIST (A151216)
Accepting Participants
Phase 1/2 Study of Stereotactic Body Radiation Therapy (SBRT) With or Without GC4711 for Early Stage, Centrally Located or Large Non-Small Cell Lung Cancer (NSCLC)(GRECO-1)
Closed
Non-small Cell Lung Cancer, Previously Treated (SWOG Lung-Map)
Closed
Phase III Comparison of Thoracic Radiotherapy Regimens in Patients With Limited Small Cell Lung Cancer Also Receiving Cisplatin and Etoposide (CALGB-30610)
Closed
Phase III Study to Determine Efficacy of Durvalumab in Stage II-III Non-small Cell Lung Cancer (NSCLC) After Curative Intent Therapy. (MERMAID-2)
Closed
Ramucirumab and Pembrolizumab Versus Standard of Care in Treating Patients With Stage IV or Recurrent Non-small Cell Lung Cancer (A Lung-MAP Non-Match Treatment Trial) (S1800A)
Closed
Small Cell Lung Cancer, Relapsed or Refractory, Second-Line (DIV-SCLC-301)
Closed
Testing the Addition of an Antibody to Standard Chemoradiation Followed by the Antibody for One Year to Standard Chemoradiation Followed by One Year of the Antibody in Patients With Unresectable Stage III Non-Small Cell Lung Cancer
Accepting Participants
Non-small Cell Lung Cancer, Early Stage, Resected, Harboring ALK (E4512)
Closed
A Randomized Phase III Trial of Induction/ Consolidation Atezolizumab (NSC #783608) + SBRT Versus SBRT Alone in High Risk, Early Stage NSCLC (S1914)
Closed
Ramucirumab Plus Pembrolizumab vs Usual Care for Treatment of Stage IV or Recurrent Non-Small Cell Lung Cancer Following Immunotherapy, Pragmatica-Lung Study (S2302 Pragmatica)
Accepting Participants
Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-small Cell Lung Cancer (NRG-LU008)
Accepting Participants

Precision Medicine & Rare Tumors

Advanced Cancer, ALT-803 in Combination With PD-1/PD-L1 Checkpoint Inhibitor (QUILT-3.055)
Closed
Non-small Cell Lung Cancer NSCLC, EGFR Mutant (A081105)
Closed

Oncology

AMG 510 (pINN) Sotorasib Activity in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation (CodeBreak 101) (Amgen 20190135 Subprotocol E)
Closed
AMG 510 in Combination with Carboplatin and Pemetrexed or with Docetaxel in Subjects with NSCLC with KRAS p.G12C Mutation (Amgen Subprotocol F)
Accepting Participants
Effects of Intravenous GC4419 on the Incidence and Severity of Esophagitis Due to Chemoradiotherapy for Lung Cancer
Complete
Integration of Immunotherapy Into Adjuvant Therapy for Resected NSCLC: ALCHEMIST Chemo-IO (A081801)
Closed
Phase III Trial of Stereotactic Radiosurgery (SRS) Versus Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) for 10 or Fewer Brain Metastases From Small Cell Lung Cancer (NRG-CC009)
Closed
Rucaparib in Treating Patients With Genomic LOH High and/or Deleterious BRCA1/2 Mutation Stage IV or Recurrent Non-small Cell Lung Cancer (A Lung-MAP Treatment Trial) (S1900A)
Closed
Testing the Timing of Pembrolizumab Alone or With Chemotherapy as First Line Treatment and Maintenance in Non-small Cell Lung Cancer (EA5163/ S1709)
Closed

Symptom Management & Cancer Control

Lung Cancer, Survivors (RELAX) (WF01213)
Closed
Non-small Cell Lung Cancer NSCLC; Stages I-II; African-American, (WF01414) Observation
Closed

Breast Cancer

Solid Tumors, Blood Sample Collection to Evaluate Biomarkers (2018-01)
Closed
Study of ORIC-114 in Patients with Advanced Solid Tumors Harboring an EGFR or HER2 Alteration (ORIC 114-01)
Accepting Participants

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