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Clinical Research Trials

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Disease Site

Oncology
Thoracic Cancer
Hematologic Cancer
Breast Cancer
Symptom Management & Cancer Control
Gastrointestinal Cancer
Genitourinary Cancer
Precision Medicine & Rare Tumors
Cancer Care Delivery Research (CCDR)
Cardiology
Head & Neck Cancer
Phase 1
Cutaneous & Sarcoma Cancer
Gynecologic Cancer
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Neo-Natal
Nephrology
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Study Type

Treatment

Oncology

Phase 1

A Phase 1/2, Study Evaluating the Safety, Tolerability, PK, and Efficacy of AMG 510 in Subjects With Solid Tumors With a Specific KRAS Mutation (CodeBreak 100) (Amgen 20170543)
Closed
AMG 510 (pINN) Sotorasib Activity in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation (CodeBreak 101) (Amgen 20190135 Subprotocol C)
Closed
Multiple Myeloma, Refractory to Lenalidomide (A061202)
Closed
Advanced Solid Tumors w/ FGF/FGFR Aberrations (TPU-TAS-120-101)
Closed

Cutaneous & Sarcoma Cancer

A Multicenter Phase II Trial of Paclitaxel With and Without Nivolumab in Taxane Naive, and Nivolumab and Cabozantinib in Taxane Pretreated Subjects With Angiosarcoma (A091902)
Closed
Blood Sample Collection to Evaluate Biomarkers in Subjects With Untreated Melanoma (ES2018-03)
Closed

Precision Medicine & Rare Tumors

Solid Tumors, Rare Tumor Types, DART (S1609)
Closed
Lymphoma, Hodgkin (CA209655) Observational
Closed
Melanoma, Stage III-IV BRAF Mutant (S1320)
Closed
Merkel Cell Carcinoma, Advanced (A091605)
Closed
Merkel Cell Carcinoma, Resected (EA6174)
Closed
Non-small Cell Lung Cancer NSCLC, EGFR Mutant (A081105)
Closed
Solid and Liquid Tumors: Newly Diagnosed With No Treatment Started (GRAIL-001) Observation
In Progress
Solid Tumors (eFT508-0010)
Closed
Advanced Cancer, ALT-803 in Combination With PD-1/PD-L1 Checkpoint Inhibitor (QUILT-3.055)
Closed
Solid Tumors or Lymphomas; MATCH (EAY131)
Closed

Thoracic Cancer

A Phase III, Randomized, Multicenter, Double-blind, Placebo-controlled Study to Determine the Efficacy of Adjuvant Durvalumab in Combination With Platinum-based Chemotherapy in Completely Resected Stage II-III NSCLC (Mermaid-1)
Closed
Adenoma and Second Primary Prevention Trial (S0820)
Closed
Limited Stage Small Cell Lung Cancer (LS-SCLC): A Phase II/III Randomized Study of Chemoradiation Versus Chemoradiation Plus Atezolizumab (NRG-LU005)
Closed
LUNGMAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer, (Screening Study)
Closed
Non-small Cell Lung Cancer, Previously Treated (SWOG Lung-Map)
Closed
Phase III Comparison of Thoracic Radiotherapy Regimens in Patients With Limited Small Cell Lung Cancer Also Receiving Cisplatin and Etoposide (CALGB-30610)
Closed
Phase III Study to Determine Efficacy of Durvalumab in Stage II-III Non-small Cell Lung Cancer (NSCLC) After Curative Intent Therapy. (MERMAID-2)
Closed
Non-small Cell Lung Cancer, Early Stage, Resected, Harboring ALK (E4512)
Closed
A Randomized Phase III Trial of Induction/ Consolidation Atezolizumab (NSC #783608) + SBRT Versus SBRT Alone in High Risk, Early Stage NSCLC (S1914)
Closed
Ramucirumab and Pembrolizumab Versus Standard of Care in Treating Patients With Stage IV or Recurrent Non-small Cell Lung Cancer (A Lung-MAP Non-Match Treatment Trial) (S1800A)
Closed
Phase 1/2 Study of Stereotactic Body Radiation Therapy (SBRT) With or Without GC4711 for Early Stage, Centrally Located or Large Non-Small Cell Lung Cancer (NSCLC)(GRECO-1)
Closed
Small Cell Lung Cancer, Relapsed or Refractory, Second-Line (DIV-SCLC-301)
Closed
Ramucirumab Plus Pembrolizumab vs Usual Care for Treatment of Stage IV or Recurrent Non-Small Cell Lung Cancer Following Immunotherapy, Pragmatica-Lung Study (S2302 Pragmatica)
In Progress

Breast Cancer

A Phase IIR/III Trial of Standard of Care Therapy With or Without Stereotactic Body Radiotherapy (SBRT) and/or Surgical Ablation for Newly Oligometastatic Breast Cancer (NGR BR002)
Closed
A Randomized, Double-Blind, Phase III Clinical Trial of Neoadjuvant Chemotherapy With Atezolizumab or Placebo in Patients With Triple-Negative Breast Cancer Followed by Adjuvant Continuation of Atezolizumab or Placebo (NSABP B-59)
Closed
A Randomized, Double-Blind, Phase III Trial of Paclitaxel/ Trastuzumab/ Pertuzumab with Atezolizumab or Placebo in First-Line HER2-Positive Metastatic Breast Cancer (NRG-BR004)
Closed
Advanced Breast Cancer (A5481082)
Closed
Breast or Gynecologic Cancer, Improving Sexual Desire (NRG-CC004)
Closed
HER2 Negative Primary Breast Cancer, gBRCA1/2 Mutations and High Risk (NSABP B-55)
Closed
High-Risk; Hormone Receptor-Positive and HER2/Neu Negative (S1207)
Closed
HER2- Positive Breast Cancer, Brain Metastasis (RTOG 1119)
Closed
High Risk, Node-Positive, Early Stage (NSABP B-58)
Closed
Post-Mastectomy and Post-Lumpectomy; Positive Axillary Nodes (NSABP B-51)
Closed
Post Mastectomy Radiation w/Breast Reconstruction (A221505)
Closed
Solid Tumors, Blood Sample Collection to Evaluate Biomarkers (2018-01)
Closed
Stage I-II Breast Cancer, MRI and Mammography Before Surgery (A011104)
Closed
Triple Receptor-Negative Breast Cancer (S1418/BR006)
Closed
Triple-Negative Basal-Like Breast Cancer (EA1131)
Closed
Triple-Negative, Node-Positive or High-Risk Node-Negative (NRG-BR003)
Closed
Weight Loss - Breast Cancer (A011401) (BWEL)
In Progress
A Phase II Randomized Trial of Olaparib (NSC-747856) Administered Concurrently with Radiotherapy versus Radiotherapy Alone for Inflammatory Breast Cancer (S1706)
Closed
FDG PET to Assess Therapeutic Response in Patients with Bone-dominant Metastatic Breast Cancer, FEATURE (EA1183)
Closed

Oncology

A Phase III Randomized Trial of Gemcitabine, Cisplatin, and Nab-Paclitaxel Versus Gemcitabine and Cisplatin in Newly Diagnosed, Advanced Biliary Tract Cancers (S1815)
Closed
Assessment Of Cognitive Function In Breast Cancer And Lymphoma Patients Receiving Chemotherapy At Pre-Treatment, Post-Treatment, At Six Month Follow-Up, And Long-Term Follow-Ups (URCC 10055)
Closed
AMG 510 (pINN) Sotorasib Activity in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation (CodeBreak 101) (Amgen 20190135 Subprotocol E)
Closed
Integration of Immunotherapy Into Adjuvant Therapy for Resected NSCLC: ALCHEMIST Chemo-IO (A081801)
Closed
Nasopharynx, Based on Biomarker EBV DNA (NRG-HN001)
Closed
Phase III Trial of Stereotactic Radiosurgery (SRS) Versus Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) for 10 or Fewer Brain Metastases From Small Cell Lung Cancer (NRG-CC009)
Closed
Randomized Phase II Trial in Early Relapsing or Refractory Follicular Lymphoma (S1608)
Closed
Rucaparib in Treating Patients With Genomic LOH High and/or Deleterious BRCA1/2 Mutation Stage IV or Recurrent Non-small Cell Lung Cancer (A Lung-MAP Treatment Trial) (S1900A)
Closed
Vitamin D3 With Chemotherapy and Bevacizumab in Treating Patients With Advanced or Metastatic Colorectal Cancer, SOLARIS (A021703)
Closed
Uterine Cervix or Vaginal Cancer, Newly Diagnosed (NRG-GY006)
Closed
Vulva, Advanced Squamous Cell, Locally Advanced (GOG-0279)
Closed
Mepitel Film for the Reduction of Radiation Dermatitis in Breast Cancer Patients Undergoing Post-Mastectomy Radiation Therapy: A Randomized Phase III Clinical Trial (A221803)
Closed
Testing the Timing of Pembrolizumab Alone or With Chemotherapy as First Line Treatment and Maintenance in Non-small Cell Lung Cancer (EA5163/ S1709)
Closed
Immunotherapy (Nivolumab or Brentuximab Vedotin) Plus Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage III-IV Classic Hodgkin Lymphoma (S1826)
Closed
A Phase 3b, Multicenter, Open-Label, Single-Arm Study of Acalabrutinib (ACP-196) in Subjects With Chronic Lymphocytic Leukemia (AZ ASSURE)
Closed
Screening Mammogram (TMIST) (EA1151)
In Progress

Hematologic Cancer

A Safety, PK and Efficacy Study of CC-92480 Monotherapy and in Combination With Dexamethasone in Subjects With Relapsed and Refractory Multiple Myeloma (RRMM) (Celegene CC-92480-MM-001)
Closed
A Study Comparing Daratumumab, VELCADE (Bortezomib), Lenalidomide, and Dexamethasone (D-VRd) With VELCADE, Lenalidomide, and Dexamethasone (VRd) in Participants With Untreated Multiple Myeloma and for Whom Hematopoietic Stem Cell Transplant is Not Planned
Closed
Blood Sample Collection to Evaluate Biomarkers in Subjects With Untreated Hematologic Malignancies (2018-02)
Closed
Leukemia, Chronic Lymphocytic (CLL), Untreated Younger Patients (EA9161)
Closed
Leukemia, Chronic Lymphocytic (CLL), Untreated Older Patients (A041702)
Closed
Leukemia, Acute Promyelocytic (EA9131) Observational
Closed
Leukemia, Chronic Lymphocytic (PCYC-1134M), Registry
Closed
Multiple Myeloma, Untreated, Stem Cell Transplant Not Planned (54767414MMY3019)
Closed
Multiple Myeloma: 1st Line Therapy (E1A11)
Closed
Myelofibrosis or Essential Thrombocythemia (INCB-MA-MF-401) Registry
Closed
Myelodysplastic Syndromes (MDS) (NHLBI-MDS) Observational
Closed
Randomized, Open-label, 2-Arm, Multicenter, Phase 3 Study of Venetoclax and Azacitidine Versus Best Supportive Care as Maintenance Therapy for Patients With Acute Myeloid Leukemia in First Remission After Conventional Chemotherapy (VIALE-M)
Closed
Study of Lenalidomide/ Ixazomib/ Dexamethasone/ Daratumumab in Transplant-Ineligible Patients With Newly Diagnosed MM (AFT-41)
Closed
Myelodysplastic Syndromes & Acute Myeloid Leukemia, (Connect® MDS/AML) Observational
Closed
A Randomized Study of Daratumumab Plus Lenalidomide Versus Lenalidomide Alone as Maintenance Treatment in Patients With Newly Diagnosed Multiple Myeloma Who Are Minimal Residual Disease Positive After Frontline Autologous Stem Cell Transplant (MMY3021)
Closed

Head & Neck Cancer

A Trial Testing Chemo Mouthpiece Device and Best Supportive Care Against Best Supportive Care Only for Symptoms of Oral Mucositis in Patients Receiving Chemotherapy (CHEM-01)
Closed
Head and Neck, Non-Metastatic, Reduce Severe Oral Mucositis (GTI-4419-301)
Closed
Head and Neck, Squamous Cell Carcinoma, Oral Mucositis (IDR-OM-02)
Closed
Head and Neck Cancer, Advanced (NRG-HN004)
Closed

Genitourinary Cancer

A Study of Salvage Radiotherapy With or Without Enzalutamide in Recurrent Prostate Cancer Following Surgery (RTOG-3506 STEEL)
Closed
Prostate, Chemo Naive, mCRPC (PANTHER)
Closed
Prostate, Unfavorable Intermediate or Favorable High Risk (RTOG 0924)
Closed
Prostate; High-Risk Biochemically Relapsed (AFT-19)
Closed
Prostate, Post-Prostatectomy (NRG-GU002)
Closed
Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors (A031102)
Closed
Urothelial, Muscle Invasive and Locally Advanced (A031501)
Closed
Immunotherapy With Nivolumab and Ipilimumab Followed by Nivolumab or Nivolumab With Cabozantinib for Patients With Advanced Kidney Cancer, The PDIGREE Study (A031704)
Closed
Phase II Study of Bladder-Sparing Chemoradiation with MEDI4736 (Durvalumab) in Clinical Stage III, Node Positive Bladder Cancer (EA8185 - INSPIRE)
Closed
Nivolumab in Treating Patients With Localized Kidney Cancer Undergoing Nephrectomy (EA8143)
Closed

Cancer Care Delivery Research (CCDR)

Assessment of Current Biomarker Testing Practices for Common Solid Cancers in Precision Oncology in the Community Setting (EAQ161CD)
Closed
Assessment of Financial Difficulty in Participants With Chronic Lymphocytic Leukemia and Multiple Myeloma (A231602CD)
Closed
Colon or Rectal Cancer, Stage I-III, Financial Burden Assessment (EAQ162CD)
Closed
Implementing Palliative Care: Learning Collaborative vs. Technical Assistance (URCC18110CD - ENABLE)
Closed
Increasing the Dose of Survivorship Care Planning in Improving Care and Outcomes in Prostate Cancer Survivors Receiving Androgen Deprivation Therapy (NRG-CC007CD)
Closed
Supportive Care Service (WF 1803CD)
Closed
Understanding the Impact of Drug Shortages on Oncology Care Delivery (URCC18004CD)
Closed
Leukemia, Acute Lymphocytic (ALL), Adolescent & Young Adult (ACCL16N1CD)
Closed
A Randomized Trial Addressing Cancer-Related Financial Hardship Through Delivery of a Proactive Financial Navigation Intervention (CREDIT) (S1912CD)
In Progress

Gastrointestinal Cancer

Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair, (A021502)
Closed
Combination Chemotherapy, Bevacizumab, and/or Atezolizumab in Treating Patients With Deficient DNA Mismatch Repair Metastatic Colorectal Cancer (NRG GI004)
Closed
Liver, Non-resectable, (RESIN) Registry
Closed
Nivolumab After Combined Modality Therapy in Treating Patients With High Risk Stage II-IIIB Anal Cancer (EA2165)
Closed
Phase II/III Study of Circulating Tumor DNA as a Predictive Biomarker in Adjuvant Chemotherapy in Patients with Stage IIA Colon Cancer (COBRA)(NRG GI005)
Closed
A Randomized Phase II Study De-Intensified Chemoradiation for Early-Stage Anal Squamous Cell Carcinoma (DECREASE) (EA2182)
In Progress
Testing the Use of BRAF-Targeted Therapy After Surgery and Usual Chemotherapy for BRAF-Mutated Colon Cancer (A022004)
Closed

Symptom Management & Cancer Control

Effect of Treatment on Work Experience in Patients With Stage I-III Prostate Cancer (WF-1802 PCW)
Closed
EROS: Engendering Reproductive Health within Oncologic Survivorship (E1Q11)
Closed
Lung Cancer, Survivors (RELAX) (WF01213)
Closed
NCI COVID-19 in Cancer Patients, NCCAPS Study (NCI COVID, N-CCaPS)
Closed
Non-small Cell Lung Cancer NSCLC; Stages I-II; African-American, (WF01414) Observation
Closed
Survivors, Work Ability in Young Adult Survivors (WF 10217)
Closed
Wireless Transcutaneous Electrical Nerve Stimulation (TENS) for Chemotherapy-Induced Peripheral Neuropathy: A Phase II Clinical Trial (URCC 19085 TENS)
Closed
Treatment Effects on Development of Chemotherapy-Induced Peripheral Neuropathy in Patients With Cancer (S1714)
Closed

Other

Cardiology

A Phase 3, Randomized, Double-Blind, Active and Placebo-Controlled Study on the use of CUSA-081 for Dysfunctional Central Venous Access Devices (CVADs)
Closed
Acute Coronary Syndrome (ACS), Cardiovascular (CV) Risk (DAL-301)
Closed
BIO-LIBRA Clinical Study (BIO-LIBRA)
Closed
PRESERVE; Inferior Vena Cava Filters (M01482)
Closed
SJM-CIP-CL1000304: SJM Brady MRI Post Approval
Closed
Validation of OCT-based Functional Diagnosis of Coronary Stenosis (FUSION)
Closed

Nephrology

ACCESS: Trial to Evaluate the Sirolimus-Eluting Collagen Implant on AV Fistula Outcomes (02513303)
Closed

Neo-Natal

Eating, Sleeping, Consoling for Neonatal Withdrawal (ESC-NOW): a Function-Based Assessment and Management Approach (ESC-NOW)
Closed

Other

Evaluation of the Clinical Performance of the Quantra System With the QStat Cartridge in Trauma and Liver Transplantation
Closed
Expanded Access to Convalescent Plasma for the Treatment of Patients with COVID-19
Closed
FLEX FIRST Registry Research Protocol (VMG-2022-001)
Closed

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