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Clinical Research Trials

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Disease Site

Oncology
Symptom Management & Cancer Control
Breast Cancer
Genitourinary Cancer
Thoracic Cancer
Cancer Care Delivery Research (CCDR)
Gastrointestinal Cancer
Cardiology
Neurologic Cancer
Precision Medicine & Rare Tumors
Cutaneous & Sarcoma Cancer
Gynecologic Cancer
Head & Neck Cancer
Orthopaedic

Study Type

Treatment
Observational

Oncology

Oncology

A Phase II Study of Checkpoint Blockade Immunotherapy in Patients With Somatically Hypermutated Recurrent WHO Grade 4 Glioma (A071702)
Accepting Participants
A Randomized Phase III Trial of Pre-Operative Compared to Post-Operative Stereotactic Radiosurgery in Patients With Resectable Brain Metastases (BN-012)
Accepting Participants
Dose Dense Gemcitabine and Cisplatin Without Cystectomy for Patients With Muscle Invasive Bladder Urothelial Cancer and Select Genetic Alterations (A031701)
Accepting Participants
Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps, FORTE (NRG-CC005)
Accepting Participants
Germ Cell Tumor, Pediatric and Adult Patients (COG AGCT1531)
Accepting Participants
Improving Adolescent and Young Adult Self-Reported Data in ECOG-ACRIN Trials (EAQ202)
Accepting Participants
Myopenia and Mechanism of Chemotherapy Toxicity in Older Adults with Colorectal Cancer: The M&M Study (WF-1806)
Accepting Participants
NCI Community Oncology Research Program (NCORP) Tissue Procurement Protocol: An NCI Cancer MoonshotSM Study
Accepting Participants
Optimizing Endocrine Therapy Adherence Through Motivational Interviewing and Text Interventions (GETSET) (A191901)
Accepting Participants
Parallel Phase III Randomized Trials for High Risk Prostate Cancer Evaluating De-Intensification for Lower Genomic Risk and Intensification of Concurrent Therapy for Higher Genomic Risk With Radiation (PREDICT-RT*)(NRG-GU009)
Accepting Participants
Parallel Phase III Randomized Trials of Genomic-Risk Stratified Unfavorable Intermediate Risk Prostate Cancer: De-Intensification and Intensification Clinical Trial Evaluation (GUIDANCE) (NRG-GU010)
Accepting Participants
Phase II Trial of Intravesical Gemcitabine and MK-3475 (Pembrolizumab) in the Treatment of Patients with BCG-Unresponsive Non-Muscle Invasive Bladder Cancer (A031803)
Accepting Participants
Disparities in Results of Immune Checkpoint Inhibitor Treatment (DIRECT): A Prospective Cohort Study of Cancer Survivors Treated with anti-PD-1/antiPD-L1 Immunotherapy in a Community Oncology Setting (URCC-21038)
Accepting Participants
AMG 510 in Combination with Carboplatin and Pemetrexed or with Docetaxel in Subjects with NSCLC with KRAS p.G12C Mutation (Amgen Subprotocol F)
Accepting Participants
Screening Mammogram (TMIST) (EA1151)
In Progress

Cutaneous & Sarcoma Cancer

A Phase II Study of Biomarker Driven Early Discontinuation of Anti-PD-1 Therapy in Patients With Advanced Melanoma (PET-Stop)
Accepting Participants

Symptom Management & Cancer Control

Blinded Reference Set for Multicancer Early Detection Blood Tests (A212102)
Accepting Participants
Randomized Placebo Controlled Trial of Bupropion For Cancer Related Fatigue (URCC 18007)
Accepting Participants
A Non-Randomized Prospective Clinical Trial Comparing the Non-Inferiority of Salpingectomy to Salpingo-Oophorectomy to Reduce the Risk of Ovarian Cancer Among BRCA1 Carriers (NRG-CC008)
Accepting Participants
Comparing Cooling and/or Compression Approaches of Limbs for Prevention of Chemotherapy-Induced Peripheral Neuropathy (S2205)
Accepting Participants
High-Dose Vitamin D Supplementation for ADT-Induced Bone Loss in Older Prostate Cancer Patients (URCC-22053 VIPER)
Accepting Participants
Cognitive Training for Cancer Related Cognitive Impairment in Breast Cancer Survivors (NRG-CC011)
Accepting Participants
Comparing Single vs Multiple Dose Radiation for Cancer Patients With Brain Metastasis and Receiving Immunotherapy (WF-2201)
Accepting Participants
Multi-site Community Oncology Planning for the CONNECT Intervention Targeting Lung Cancer Caregivers (WF-2301CD)
Accepting Participants
An Observational Research Study to Uncover Subtypes of Cancer Cachexia, LOTUS-CC Study (URCC-22063)
Accepting Participants
All Disease Sites; Health Disparities (DCP-001)
Accepting Participants

Cancer Care Delivery Research (CCDR)

Does the Use of a Genomic Tumor Board Increase the Number of Patients Who Receive Genome-Informed Treatment
Accepting Participants
Implementation and Effectiveness Trial of HN-STAR (WF-1805CD)
Accepting Participants
A Randomized Trial Addressing Cancer-Related Financial Hardship Through Delivery of a Proactive Financial Navigation Intervention (CREDIT) (S1912CD)
In Progress

Thoracic Cancer

MRI Brain Surveillance Alone Versus MRI Surveillance and Prophylactic Cranial Irradiation (PCI): A Randomized Phase III Trial in Small-Cell Lung Cancer (MAVERICK) (S1827)
Accepting Participants
Non-small Cell Lung Cancer ALCHEMIST (A151216)
Accepting Participants
Testing the Addition of an Antibody to Standard Chemoradiation Followed by the Antibody for One Year to Standard Chemoradiation Followed by One Year of the Antibody in Patients With Unresectable Stage III Non-Small Cell Lung Cancer
Accepting Participants
Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-small Cell Lung Cancer (NRG-LU008)
Accepting Participants
Ramucirumab Plus Pembrolizumab vs Usual Care for Treatment of Stage IV or Recurrent Non-Small Cell Lung Cancer Following Immunotherapy, Pragmatica-Lung Study (S2302 Pragmatica)
In Progress

Genitourinary Cancer

Randomized Phase II/III Trial of Consolidation Radiation + Immunotherapy for ES-SCLC: RAPTOR Trial (NRG LU007)
Accepting Participants
Chemoradiotherapy With or Without Atezolizumab in Treating Patients With Localized Muscle Invasive Bladder Cancer (S1806)
Closed
Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer (NRG-GU013)
Accepting Participants

Precision Medicine & Rare Tumors

Solid and Liquid Tumors: Newly Diagnosed With No Treatment Started (GRAIL-001) Observation
In Progress

Breast Cancer

Weight Loss - Breast Cancer (A011401) (BWEL)
In Progress
Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/NSABP B-63)
Accepting Participants
Ribociclib vs. Palbociclib in Patients With Advanced Breast Cancer Within the HER2-Enriched Intrinsic Subtype (AFT-58)
Accepting Participants
A Phase II Trial of Sacituzumab Govitecan (IMMU-132) (NSC #820016) for Patients With HER2-Negative Breast Cancer and Brain Metastases (S2007)
Accepting Participants
A Study of Camizestrant in ER+/HER2- Early Breast Cancer After at Least 2 Years of Standard Adjuvant Endocrine Therapy (NSABP B-62 CAMBRIA-1)
Accepting Participants
Study of ORIC-114 in Patients with Advanced Solid Tumors Harboring an EGFR or HER2 Alteration (ORIC 114-01)
Accepting Participants
T-DM1 and Tucatinib Compared With T-DM1 Alone in Preventing Relapses in People With High Risk HER2-Positive Breast Cancer, the CompassHER2 RD Trial (A011801)
Accepting Participants
Regional Radiotherapy in Biomarker Low-Risk Node Positive and T3N0 Breast Cancer (CCTG MA.39)
Accepting Participants
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25 (NRG BR009)
Accepting Participants

Gastrointestinal Cancer

Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease (NRG-GI008)
Accepting Participants
The Janus Rectal Cancer Trial: A Randomized Phase II Trial Testing the Efficacy of Triplet Versus Doublet Chemotherapy to Achieve Clinical Complete Response in Patients with Locally Advanced Rectal Cancer (A022104)
Accepting Participants
A Randomized Phase II Study De-Intensified Chemoradiation for Early-Stage Anal Squamous Cell Carcinoma (DECREASE) (EA2182)
In Progress

Head & Neck Cancer

A Randomized Phase II/III Trial of De-Intensified Radiation Therapy for Patients With Early-Stage, P16-Positive, Non-Smoking Associated Oropharyngeal Cancer (NRG HN005)
Accepting Participants

Other

Cardiology

Effect of Dalcetrapib on CV Risk in a Genetically Defined Population With a Recent ACS (Dal-GenE-2 DAL-302)
Accepting Participants
SAVE-FistulaS: the SelfWrap-Assisted ArterioVEnous Fistula Study (VENO-CIP002 SAVE)
Accepting Participants

Orthopaedic

BioBrace® Implant for Arthroscopic Repair of Full Thickness Rotator Cuff Tears (CSP-BB0003)
Accepting Participants

Oncology

A Study of LSTA1 When Added to Standard of Care Versus Standard of Care Alone in Patients with Advanced Solid Tumors (LSTA1-P02 BOLSTER)
Accepting Participants

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